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The Kansas City Chiefs put running back Clyde Edwards-Helaire on the reserve/non-football illness list, meaning he will miss at least four games, ESPN reported Monday.

In anticipation of Edwards-Helaire’s absence, the Chiefs signed RB Samaje Perine last week after his release from the Denver Broncos. Head coach Andy Reid said Perine will be available to play Thursday when the defending Super Bowl champion Chiefs open the season against the visiting Baltimore Ravens.

The Chiefs selected Edwards-Helaire in the first round of the 2020 NFL Draft out of LSU. In 48 games (32 starts) over four seasons, he has rushed 441 times for 1,845 yards with 12 touchdowns. He’s added 765 receiving yards and seven scores.

Last month, Edwards-Helaire, 25, revealed on social media and also shared with reporters at training camp that he has been impacted by post-traumatic stress disorder since December 2018.

“Sometimes I’m admitted into the hospital, something like I can’t stop throwing up and it’s just, I (don’t) know (anything) pretty much to stop it,” he said, per ESPN.

“Real bad dehydration … but it’s really just mentally just not being there,” he said, adding alert teammates can notice that, “‘OK, Clyde’s not laughing, he’s not giggling, he’s not himself.'”

Edwards-Helaire did not disclose the cause of his PTSD, other than to cite “a self-defense situation” that he went through in college.

Isiah Pacheco is listed on the Chiefs’ depth chart as the No. 1 running back.

–Field Level Media