Top-ranked Alabama has been installed as the biggest favorite in College Football Playoff history to win its semifinal game against No. 4 Notre Dame.
The Crimson Tide were listed as 19-point favorites shortly after the release of the CFP matchups on Sunday. That broke Alabama’s own previous CFP record as a 14.5-point favorite over Oklahoma in 2018-19, according to SportsBetting.com.
The sportsbook set the over/under point total for the Alabama-Notre Dame game at 65.5 points.
No. 2 Clemson is a 7-point favorite to beat third-seeded Ohio State in the other semifinal, with SportsBetting.com offering the over/under at 65 points.

Largest CFP Spreads in history (SportsBetting.com)
- 2020/21 Rose Bowl: Alabama (-19) vs. Notre Dame
- 2018/19 Orange Bowl: Alabama (-14.5) vs. Oklahoma
- 2019/20 Peach Bowl: LSU (-12.5) vs. Oklahoma
- 2016/17 Peach Bowl: Alabama (-12.5) vs. Washington
- 2018/19 Cotton Bowl: Clemson (-10.5) vs. Notre Dame
- 2015/16 Cotton Bowl: Alabama (-10) vs. Michigan State
- 2014/15 Sugar Bowl: Alabama (-7.5) vs. Ohio State
- 2014/15 Rose Bowl: Oregon (-7.5) vs. Florida State
- 2020/21 Sugar Bowl: Clemson (-7) vs. Ohio State
Favorites are 9-3 straight up and 8-4 against the spread in semifinal history, according to the sportsbook.
Biggest CFP upsets in history (SportsBetting.com)
- 2014/15 Sugar Bowl: Ohio State (+7.5) over Alabama
- 2016/17 CFP NCG: Clemson (+6.5) over Alabama
- 2014/15 CFP NCG: Ohio State (+6) vs. Oregon
- 2018/19 CFP NCG: Clemson (+5) over Alabama
- 2015/16 Orange Bowl: Clemson (+3.5) over Oklahoma
- 2016/17 Fiesta Bowl: Clemson (+1) over Ohio State

Alabama is also the heavy favorite to win the national title, with the Crimson Tide being offered at -175 by SportsBetting.com. Clemson is +200, followed by Ohio State at +600. Notre Dame has by far the longest odds at +1800.
–Field Level Media (@FieldLevelMedia)