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Fresh off the best rushing game of his career, Detroit Lions third-year running back D’Andre Swift missed Wednesday’s practice with an ankle injury.

In what could be a telling move, the Lions signed RB Justin Jackson to the active roster from the practice squad.

Swift, 23, rushed for a career-high 144 yards in Sunday’s loss to the Philadelphia Eagles. He averaged 9.6 yards per carry and scored a touchdown. He also caught three passes for 31 yards. It’s unclear when or how Swift was injured. He played 67 percent of Detroit’s offensive snaps.

Jamaal Williams is the No. 2 running back. He rushed 11 times for 28 yards and two touchdowns against the Eagles.

Jackson was on the active roster for Week 1 and played 20 snaps on special teams. He has 1,040 career rushing yards and four touchdowns in 43 games (seven starts) with the Los Angeles Chargers.

Also, Lions center Frank Ragnow (groin) and left tackle Taylor Decker (undisclosed) missed practice Wednesday. Halapoulivaati Vaitai is already on injured reserve and backup guard Tommy Kraemer (back) remains out.

“Frank’s a little sore,” Lions coach Dan Campbell said Wednesday. “He won’t practice today, so we’re just going to monitor him and see how he feels. It is, it’s kind of a day-to-day, and see where we go with it.”

The team also re-signed tackle Darrin Paulo to the practice squad.

–Field Level Media